RB · San Francisco 49ers
Isaac Guerendo
Age 25 · 183 cm (6'0") · 100 kg · Born Jun 28, 2000 · Louisville; Wisconsin
NFL career
2024
debut year
2026
last season
3
seasons
#31
jersey
College: Louisville; Wisconsin
Career stats
Regular-season totals from 2024 to 2025 · 23 games.
Rushing
420yards
4touchdowns
84carries
5.0YPC avg
Stats by season
2 regular-season campaigns tracked.
Rushing
| Year | Team | G | Carries | Yards | Avg | TD |
|---|---|---|---|---|---|---|
| 2024 | San Francisco 49ers | 16 | 84 | 420 | 5.0 | 4 |
| 2025 | San Francisco 49ers | 7 | 0 | 0 | — | 0 |
Games during career · San Francisco 49ers
Most recent results for the franchise while Isaac Guerendo was on the roster (1999+ play-by-play coverage).
L
W
L
W
W
W
W
W
6–41 @ Seahawks
2025-20 · Jan 17, 2026 · PLAYOFF
W
23–19 @ Eagles
2025-19 · Jan 11, 2026 · PLAYOFF
L
3–13 vs Seahawks
2025-18 · Jan 3, 2026 · REGULAR
W
42–38 vs Bears
2025-17 · Dec 28, 2025 · REGULAR
W
48–27 @ Colts
2025-16 · Dec 22, 2025 · REGULAR
W
37–24 vs Titans
2025-15 · Dec 14, 2025 · REGULAR
W
26–8 @ Browns
2025-13 · Nov 30, 2025 · REGULAR
W
20–9 vs Panthers
2025-12 · Nov 24, 2025 · REGULAR
Career badges
Active player
External profiles
Louisville alumni in the NFL
Other NFL players who attended Louisville.
Ashton Gillotte
DE · 2025 · Chiefs
Corey Thornton
CB · 2025 · Panthers
Ja'Corey Brooks
WR · 2025 · Commanders
Mark Redman
TE · 2025 · Rams
Quincy Riley
CB · 2025 · Saints
Tyler Shough
QB · 2025 · Saints
Bryan Hudson
C · 2024 · Giants
Jack Plummer
QB · 2024 · Panthers
Jamari Thrash
WR · 2024 · Browns
Jarvis Brownlee Jr.
DB · 2024 · Jets
2024 NFL Draft · Round 4 class
Other players selected in the same round.
#101
#102
#103
#105
#106
#107
#110
Ja'Tavion Sanders
TE · CAR
#102
Troy Franklin
WR · DEN
#103
Layden Robinson
G · NWE
#104
Dadrion Taylor-Demerson
SAF · ARI
#105
Justin Eboigbe
DT · LAC
#106
Cedric Gray
LB · TEN
#107
Theo Johnson
TE · NYG
#108
#109
Khyree Jackson
MIN
Brandon Dorlus
DE · ATL
#110
Javon Baker
WR · NWE
#111
Evan Williams
SAF · GNB
#112
Decamerion Richardson
CB · LVR
RB peers of the era
Other RBs who debuted within five seasons of Isaac Guerendo.
