DE · Cleveland Browns
Isaiah McGuire
Age 24 · 193 cm (6'4") · 122 kg · Born Jul 27, 2001 · Missouri
NFL career
2023
debut year
2026
last season
4
seasons
#57
jersey
College: Missouri
2023 NFL Draft
Rd 4
round
#126
overall pick
CLE
drafted by
Career stats
Regular-season totals from 2023 to 2025 · 30 games.
Defense
31solo tackles
5.5sacks
0INTs
0def TDs
Stats by season
3 regular-season campaigns tracked.
Defense
| Year | Team | G | Tackles | Sacks | Int | Def TD |
|---|---|---|---|---|---|---|
| 2023 | Cleveland Browns | 2 | 4 | 1.0 | 0 | 0 |
| 2024 | Cleveland Browns | 13 | 14 | 2.5 | 0 | 0 |
| 2025 | Cleveland Browns | 15 | 13 | 2.0 | 0 | 0 |
Games during career · Cleveland Browns
Most recent results for the franchise while Isaiah McGuire was on the roster (1999+ play-by-play coverage).
W
W
L
L
L
L
W
L
20–18 @ Bengals
2025-18 · Jan 4, 2026 · REGULAR
W
13–6 vs Steelers
2025-17 · Dec 28, 2025 · REGULAR
L
20–23 vs Bills
2025-16 · Dec 21, 2025 · REGULAR
L
3–31 @ Bears
2025-15 · Dec 14, 2025 · REGULAR
L
29–31 vs Titans
2025-14 · Dec 7, 2025 · REGULAR
L
8–26 vs 49ers
2025-13 · Nov 30, 2025 · REGULAR
W
24–10 @ Raiders
2025-12 · Nov 23, 2025 · REGULAR
L
16–23 vs Ravens
2025-11 · Nov 16, 2025 · REGULAR
Other "McGuire" players in NFL history
Different players, same surname — ordered by most recent.
Career badges
Active player
External profiles
Missouri alumni in the NFL
Other NFL players who attended Missouri.
Armand Membou
OT · 2025 · Jets
Brady Cook
QB · 2025 · Jets
Harrison Mevis
K · 2025 · Rams
Jacardia Wright
RB · 2025 · Seahawks
Johnny Walker Jr.
LB · 2025 · Broncos
Kristian Williams
DT · 2025 · Broncos
Luther Burden III
WR · 2025 · Bears
Marcus Bryant
OT · 2025 · Patriots
Theo Wease Jr.
WR · 2025 · Dolphins
C.J. Ravenell
DE · 2024 · Titans
2023 NFL Draft · Round 4 class
Other players selected in the same round.
#103
#106
#107
#109
#110
#111
#112
Nick Saldiveri
G · NOR
#104
Jakorian Bennett
DB · LVR
#105
Kelee Ringo
CB · PHI
#106
Blake Freeland
OT · IND
#107
Jake Andrews
C · NWE
#108
Anthony Bradford
G · SEA
#109
Dylan Horton
DE · HOU
#110
Adetomiwa Adebawore
DT · IND
#111
Dawand Jones
OT · CLE
#112
Chad Ryland
K · NWE
#113
#114
Clark Phillips
ATL
Chandler Zavala
G · CAR
DE peers of the era
Other DEs who debuted within five seasons of Isaiah McGuire.
Ali Gaye
Debut 2023 · #95 · Texans
Andrew Farmer
Debut 2023 · #50 · 49ers
BJ Thompson
Debut 2023 · #53 · Chiefs
Brenton Cox Jr.
Debut 2023 · #57 · Packers
Colby Wooden
Debut 2023 · #96 · Colts
David Agoha
Debut 2023 · #58 · Titans
Desjuan Johnson
Debut 2023 · #94 · Rams
DJ Coleman
Debut 2023 · #54 · Jaguars
Born on July 27
Haven Moses
1946 · Denver Broncos
Bob Klein
1947 · Los Angeles Chargers
Reggie McKenzie
1950 · Seattle Seahawks
John Babinecz
1950 · Chicago Bears
Al Simpson
1951 · New York Giants
Charles Cornelius
1952 · San Francisco 49ers
Mike Hartenstine
1953 · Minnesota Vikings
Randy Clark
1957 · Atlanta Falcons