By surface
| Surface | Kevin Anderson | Karen Khachanov |
|---|---|---|
| Hard | 1 | 2 |
All meetings (3)
| Date | Tour | Tournament | Round | Surface | Winner | Set 1 | Set 2 | Set 3 | Set 4 | Set 5 |
|---|---|---|---|---|---|---|---|---|---|---|
| 2021-08-16 | ATP | Cincinnati Masters | Round of 64 | Hard | Karen Khachanov | 2-6 | 4-6 | |||
| 2021-02-01 | ATP | Great Ocean Road Open | Round of 16 | Hard | Karen Khachanov | 3-6 | 6-75 | |||
| 2018-03-19 | ATP | Miami Masters | Round of 32 | Hard | Kevin Anderson | 4-6 | 6-2 | 6-3 |