100 players who wore #22.
| # | Player | Position | Citizenship | Club | Caps | Intl goals |
|---|---|---|---|---|---|---|
| 1 |  Maya Yoshida | Defender - Centre-Back | Japan | Los Angeles Galaxy | 127 | 12 |
| 2 |  Martín Cáceres | Defender - Centre-Back | Uruguay | Without Club | 116 | 4 |
| 3 |  Fabian Schär | Defender - Centre-Back | Switzerland | Newcastle United | 86 | 8 |
| 4 |  Tomáš Souček | Midfield - Defensive Midfield | Czech Republic | West Ham United | 81 | 15 |
| 5 |  Aurélien Joachim | Attack - Centre-Forward | Luxembourg | FC Arlon | 80 | 15 |
| 6 |  Torsten Frings | Midfield - Defensive Midfield | Germany | Retired | 79 | 10 |
| 7 |  Mykola Matvienko | Defender - Centre-Back | Ukraine | Shakhtar Donetsk | 79 | 0 |
| 8 |  Jackson Irvine | Midfield - Central Midfield | Australia Scotland | FC St. Pauli | 76 | 11 |
| 9 |  Zach Muscat | Defender - Centre-Back | Malta | GD Chaves | 74 | 3 |
| 10 |  Lautaro Martínez | Attack - Centre-Forward | Argentina | Inter Milan | 72 | 33 |
| 11 |  Hirving Lozano | Attack - Left Winger | Mexico | San Diego FC | 70 | 18 |
| 12 |  Kenneth Omeruo | Defender - Centre-Back | Nigeria | CFR Cluj | 69 | 1 |
| 13 |  Denzel Dumfries | Defender - Right-Back | Netherlands Aruba | Inter Milan | 67 | 11 |
| 14 |  Nacer Chadli | Attack - Left Winger | Belgium Morocco | Without Club | 66 | 8 |
| 15 |  Richie Laryea | Defender - Right-Back | Canada Ghana | Toronto FC | 66 | 1 |
| 16 |  Dabao Yu | Defender - Centre-Back | China | Retired | 65 | 19 |
| 17 |  Stanislav Lobotka | Midfield - Defensive Midfield | Slovakia | SSC Napoli | 65 | 4 |
| 18 |  Jón Dadi Bödvarsson | Attack - Centre-Forward | Iceland | UMF Selfoss | 64 | 4 |
| 19 |  Brad Guzan | Goalkeeper | United States Poland | Atlanta United FC | 64 | 0 |
| 20 |  Kevin Doyle | Attack - Centre-Forward | Ireland | Retired | 63 | 14 |
| 21 |  Eduardo | Attack - Centre-Forward | Croatia Brazil | Retired | 62 | 29 |
| 22 |  David Rozehnal | Defender - Centre-Back | Czech Republic | TJ Sokol Kozusany | 60 | 1 |
| 23 |  Jussi Jääskeläinen | Goalkeeper | Finland | Retired | 58 | 0 |
| 24 |  Ronald Matarrita | Defender - Left-Back | Costa Rica | LD Alajuelense | 57 | 3 |
| 25 |  Lukasz Fabianski | Goalkeeper | Poland | West Ham United | 57 | 0 |
| 26 |  Jesús Navas | Defender - Right-Back | Spain | Retired | 56 | 5 |
| 27 |  Paul Aguilar | Defender - Right-Back | Mexico | Retired | 55 | 5 |
| 28 |  Robin Quaison | Attack - Centre-Forward | Sweden Ghana | Without Club | 52 | 14 |
| 29 |  Ezequiel Lavezzi | Attack - Second Striker | Argentina Italy | Retired | 51 | 9 |
| 30 |  Zdravko Kuzmanovic | Midfield - Central Midfield | Serbia Switzerland | Retired | 51 | 6 |
| 31 |  Alexander Callens | Defender - Centre-Back | Peru Spain | AEK Athens | 51 | 3 |
| 32 |  Amir Abrashi | Midfield - Defensive Midfield | Albania Switzerland | Grasshopper Club Zurich | 51 | 1 |
| 33 |  Faryd Mondragón | Goalkeeper | Colombia Lebanon | Retired | 51 | 0 |
| 34 |  Giovanni Di Lorenzo | Defender - Right-Back | Italy | SSC Napoli | 50 | 5 |
| 35 |  Marko Simic | Defender - Centre-Back | Montenegro Serbia | FK Liepaja | 50 | 2 |
| 36 |  Ismaël Bennacer | Midfield - Defensive Midfield | Algeria France | GNK Dinamo Zagreb | 50 | 2 |
| 37 |  Meshaal Barsham | Goalkeeper | Qatar Sudan | Al-Sadd SC | 50 | 0 |
| 38 |  Paul Hall | Attack - Centre-Forward | Jamaica England | Retired | 48 | 14 |
| 39 |  Lars Hirschfeld | Goalkeeper | Canada Germany | Retired | 48 | 0 |
| 40 |  Adem Ljajic | Midfield - Attacking Midfield | Serbia | FK Sarajevo | 47 | 9 |
| 41 |  Sol Bamba | Defender - Centre-Back | Cote d'Ivoire France | --- | 46 | 1 |
| 42 |  Chang-hoon Kwon | Attack - Right Winger | Korea, South | Jeonbuk Hyundai Motors | 43 | 12 |
| 43 |  Takehiro Tomiyasu | Defender - Centre-Back | Japan | Without Club | 42 | 1 |
| 44 |  Johan Vonlanthen | Midfield - Left Midfield | Switzerland Colombia | Retired | 40 | 7 |
| 45 |  Georges Mikautadze | Attack - Centre-Forward | Georgia France | Villarreal CF | 39 | 21 |
| 46 |  Isco | Midfield - Attacking Midfield | Spain | Real Betis Balompié | 39 | 12 |
| 47 |  Omar Marmoush | Attack - Centre-Forward | Egypt Canada | Manchester City | 39 | 7 |
| 48 |  Marvin Martins | Defender - Centre-Back | Luxembourg Cape Verde | FC Winterthur | 39 | 3 |
| 49 |  Andreas Samaris | Midfield - Defensive Midfield | Greece | Without Club | 39 | 1 |
| 50 |  Martin Petras | Defender - Right-Back | Slovakia | Retired | 39 | 1 |
| 51 |  Andri Gudjohnsen | Attack - Centre-Forward | Iceland | Blackburn Rovers | 36 | 10 |
| 52 |  Valentino Lazaro | Defender - Right-Back | Austria | Torino FC | 36 | 3 |
| 53 |  Sargis Adamyan | Attack - Centre-Forward | Armenia | 1.FC Köln II | 36 | 2 |
| 54 |  Cristian Săpunaru | Defender - Centre-Back | Romania | Retired | 36 | 0 |
| 55 |  Ben Brereton Díaz | Attack - Centre-Forward | Chile England | Derby County | 35 | 7 |
| 56 |  Marko Devic | Attack - Centre-Forward | Ukraine Serbia | Retired | 35 | 7 |
| 57 |  Viktor Pecovsky | Midfield - Defensive Midfield | Slovakia | TJ Divina | 35 | 1 |
| 58 |  Devon Williams | Midfield - Central Midfield | Jamaica | Lexington SC | 35 | 1 |
| 59 |  Manuel Iturra | Midfield - Defensive Midfield | Chile Italy | Retired | 35 | 1 |
| 60 |  Maxime Agueh | Goalkeeper | Benin France | Retired | 35 | 0 |
| 61 |  Zeca | Midfield - Central Midfield | Greece Portugal | Retired | 34 | 2 |
| 62 |  Markus Rosenberg | Attack - Centre-Forward | Sweden | Retired | 33 | 6 |
| 63 |  Javorn Stevens | Attack - Centre-Forward | Antigua and Barbuda | Hoppers FC | 33 | 3 |
| 64 |  Paulius Golubickas | Midfield - Attacking Midfield | Lithuania | Kuopion Palloseura | 33 | 2 |
| 65 |  Rafael Romo | Goalkeeper | Venezuela Spain | CD Universidad Católica | 33 | 0 |
| 66 |  Stephan El Shaarawy | Attack - Left Winger | Italy Egypt | AS Roma | 32 | 7 |
| 67 |  Konstantinos Stafylidis | Defender - Left-Back | Greece | APOEL Nicosia | 32 | 2 |
| 68 |  Nathan Collins | Defender - Centre-Back | Ireland | Brentford FC | 32 | 2 |
| 69 |  Andy Keogh | Attack - Centre-Forward | Ireland Australia | Dianella White Eagles SC | 31 | 2 |
| 70 |  Aleksejs Saveljevs | Midfield - Central Midfield | Latvia | FK Liepaja | 31 | 1 |
| 71 |  Giuseppe Rossi | Attack - Centre-Forward | Italy United States | Retired | 30 | 7 |
| 72 |  Amr Warda | Attack - Left Winger | Egypt | AE Larisa | 30 | 1 |
| 73 |  Aquivaldo Mosquera | Defender - Centre-Back | Colombia Mexico | Retired | 30 | 1 |
| 74 |  Zack Steffen | Goalkeeper | United States | Colorado Rapids | 30 | 0 |
| 75 |  David Raum | Defender - Left-Back | Germany | RB Leipzig | 30 | 0 |
| 76 |  Opa Sangante | Defender - Centre-Back | Guinea-Bissau France | USL Dunkerque | 30 | 0 |
| 77 |  Armando Broja | Attack - Centre-Forward | Albania England | Burnley FC | 29 | 5 |
| 78 |  Javier Pastore | Midfield - Attacking Midfield | Argentina Italy | Retired | 29 | 2 |
| 79 |  Evgeniy Aldonin | Midfield - Defensive Midfield | Russia | Retired | 29 | 0 |
| 80 |  Éric Scott | Attack - Centre-Forward | Costa Rica Guatemala | Retired | 28 | 7 |
| 81 |  Greg Leigh | Defender - Left-Back | Jamaica England | Oxford United | 27 | 1 |
| 82 |  Andrew Durante | Defender - Centre-Back | New Zealand Australia | Retired | 27 | 0 |
| 83 |  Jeffry Fortes | Defender - Right-Back | Cape Verde Netherlands | FC Den Bosch | 26 | 0 |
| 84 |  Young-woo Seol | Defender - Right-Back | Korea, South | Red Star Belgrade | 26 | 0 |
| 85 |  Mehdi Mostefa | Midfield - Defensive Midfield | Algeria France | Retired | 25 | 0 |
| 86 |  Garath McCleary | Attack - Right Winger | Jamaica England | Gillingham FC | 24 | 3 |
| 87 |  Jérôme Mombris | Defender - Left-Back | Madagascar France | Afa FA | 24 | 0 |
| 88 |  Serkan Balcı | Defender - Right-Back | Türkiye | Retired | 24 | 0 |
| 89 |  Frank Acheampong | Attack - Left Winger | Ghana | Henan FC | 23 | 2 |
| 90 |  Ciaron Brown | Defender - Centre-Back | Northern Ireland England | Oxford United | 23 | 0 |
| 91 |  Pablo Ibáñez | Defender - Centre-Back | Spain | Retired | 23 | 0 |
| 92 |  Everton Ribeiro | Midfield - Attacking Midfield | Brazil | Esporte Clube Bahia | 22 | 3 |
| 93 |  Marco Zoro | Defender - Centre-Back | Cote d'Ivoire | Retired | 22 | 1 |
| 94 |  Valeriy Luchkevych | Defender - Right-Back | Ukraine | Without Club | 22 | 0 |
| 95 |  Mark McKenzie | Defender - Centre-Back | United States Jamaica | FC Toulouse | 22 | 0 |
| 96 |  Erkan Zengin | Attack - Left Winger | Sweden Türkiye | IFK Haninge | 21 | 3 |
| 97 |  Bruno Miranda | Attack - Centre-Forward | Bolivia | SD Aucas | 21 | 3 |
| 98 |  Kyriakos Stamatopoulos | Goalkeeper | Canada Greece | Retired | 21 | 0 |
| 99 |  Ádám Bogdán | Goalkeeper | Hungary | Retired | 21 | 0 |
| 100 |  Georgiy Sudakov | Midfield - Attacking Midfield | Ukraine | SL Benfica | 20 | 6 |