| # | Player | Position | Citizenship | Club | League goals | Assists | Apps | Seasons |
|---|---|---|---|---|---|---|---|---|
| 1 |  Harry Kane | Attack - Centre-Forward | England Ireland | Bayern Munich | 213 | 49 | 320 | 12 |
| 2 |  Wayne Rooney | Attack - Centre-Forward | England | Retired | 208 | 109 | 491 | 17 |
| 3 |  Andy Cole | Attack - Centre-Forward | England Jamaica | Retired | 187 | 70 | 414 | 15 |
| 4 |  Mohamed Salah | Attack - Right Winger | Egypt | Liverpool FC | 187 | 89 | 304 | 11 |
| 5 |  Sergio Agüero | Attack - Centre-Forward | Argentina Spain | Retired | 184 | 48 | 275 | 10 |
| 6 |  Frank Lampard | Midfield - Central Midfield | England | Retired | 177 | 118 | 611 | 20 |
| 7 |  Thierry Henry | Attack - Centre-Forward | France Guadeloupe | Retired | 175 | 76 | 258 | 9 |
| 8 |  Jermain Defoe | Attack - Centre-Forward | England St. Lucia | Retired | 163 | 29 | 496 | 19 |
| 9 |  Michael Owen | Attack - Centre-Forward | England | Retired | 150 | 40 | 326 | 16 |
| 10 |  Teddy Sheringham | Attack - Centre-Forward | England | Retired | 146 | 70 | 417 | 14 |
| 11 |  Jamie Vardy | Attack - Centre-Forward | England | US Cremonese | 145 | 50 | 342 | 10 |
| 12 |  Robin van Persie | Attack - Centre-Forward | Netherlands | Retired | 144 | 59 | 280 | 11 |
| 13 |  Jimmy Floyd Hasselbaink | Attack - Centre-Forward | Netherlands Suriname | Retired | 127 | 53 | 288 | 9 |
| 14 |  Heung-min Son | Attack - Left Winger | Korea, South | Los Angeles FC | 127 | 77 | 333 | 10 |
| 15 |  Robbie Keane | Attack - Centre-Forward | Ireland | Retired | 126 | 37 | 349 | 13 |
| 16 |  Nicolas Anelka | Attack - Centre-Forward | France Martinique | Retired | 125 | 50 | 364 | 14 |
| 17 |  Dwight Yorke | Attack - Centre-Forward | Trinidad and Tobago England | Retired | 123 | 53 | 375 | 15 |
| 18 |  Raheem Sterling | Attack - Right Winger | England Jamaica | Chelsea FC | 123 | 75 | 396 | 14 |
| 19 |  Steven Gerrard | Midfield - Central Midfield | England | Retired | 121 | 97 | 504 | 17 |
| 20 |  Romelu Lukaku | Attack - Centre-Forward | Belgium DR Congo | SSC Napoli | 121 | 37 | 278 | 9 |
| 21 |  Dion Dublin | Attack - Centre-Forward | England | Retired | 111 | 29 | 312 | 12 |
| 22 |  Sadio Mané | Attack - Left Winger | Senegal | Al-Nassr FC | 111 | 43 | 263 | 8 |
| 23 |  Ryan Giggs | Midfield - Left Midfield | Wales | Retired | 108 | 168 | 632 | 22 |
| 24 |  Paul Scholes | Midfield - Central Midfield | England | Retired | 107 | 61 | 499 | 19 |
| 25 |  Peter Crouch | Attack - Centre-Forward | England Ireland | Retired | 106 | 62 | 468 | 18 |