| # | Player | Position | Citizenship | Club | League goals | Assists | Apps | Seasons |
|---|---|---|---|---|---|---|---|---|
| 1 |  Lionel Messi | Attack - Right Winger | Argentina Spain | Inter Miami CF | 474 | 216 | 520 | 17 |
| 2 |  Cristiano Ronaldo | Attack - Centre-Forward | Portugal | Al-Nassr FC | 311 | 95 | 292 | 9 |
| 3 |  Karim Benzema | Attack - Centre-Forward | France Algeria | Al-Ittihad Club | 238 | 112 | 439 | 14 |
| 4 |  Raúl | Attack - Second Striker | Spain | Retired | 228 | 101 | 550 | 16 |
| 5 |  Antoine Griezmann | Attack - Second Striker | France | Atlético de Madrid | 198 | 97 | 533 | 16 |
| 6 |  David Villa | Attack - Centre-Forward | Spain | Retired | 185 | 54 | 352 | 11 |
| 7 |  Luis Suárez | Attack - Centre-Forward | Uruguay | Inter Miami CF | 176 | 84 | 258 | 8 |
| 8 |  Iago Aspas | Attack - Centre-Forward | Spain | Celta de Vigo | 165 | 70 | 391 | 14 |
| 9 |  Samuel Eto'o | Attack - Centre-Forward | Cameroon Spain | Retired | 162 | 44 | 280 | 11 |
| 10 |  Aritz Aduriz | Attack - Centre-Forward | Spain | Retired | 158 | 54 | 443 | 16 |
| 11 |  Raúl Tamudo | Attack - Centre-Forward | Spain | Retired | 146 | 26 | 407 | 17 |
| 12 |  Roberto Soldado | Attack - Centre-Forward | Spain | Retired | 129 | 36 | 325 | 13 |
| 13 |  Diego Forlán | Attack - Centre-Forward | Uruguay Spain | Retired | 128 | 26 | 240 | 7 |
| 14 |  Álvaro Negredo | Attack - Centre-Forward | Spain | Retired | 128 | 44 | 361 | 12 |
| 15 |  Fernando Morientes | Attack - Centre-Forward | Spain | Retired | 124 | 19 | 337 | 15 |
| 16 |  Ronaldo | Attack - Centre-Forward | Brazil Spain | Retired | 117 | 34 | 164 | 6 |
| 17 |  Davor Suker | Attack - Centre-Forward | Croatia | Retired | 114 | 12 | 239 | 8 |
| 18 |  Raúl García | Midfield - Attacking Midfield | Spain | Retired | 111 | 50 | 609 | 20 |
| 19 |  Cristhian Stuani | Attack - Centre-Forward | Uruguay Italy | Girona FC | 111 | 18 | 326 | 11 |
| 20 |  Rivaldo | Midfield - Attacking Midfield | Brazil Spain | Retired | 107 | 39 | 198 | 6 |
| 21 |  Gonzalo Higuaín | Attack - Centre-Forward | Argentina France | Retired | 107 | 45 | 190 | 7 |
| 22 |  Fernando Torres | Attack - Centre-Forward | Spain | Retired | 102 | 15 | 281 | 9 |
| 23 |  Roy Makaay | Attack - Centre-Forward | Netherlands | Retired | 100 | 15 | 205 | 6 |
| 24 |  Diego Tristán | Attack - Centre-Forward | Spain | Retired | 96 | 21 | 227 | 8 |
| 25 |  Víctor Fernández | Attack - Centre-Forward | Spain | Retired | 94 | 28 | 341 | 12 |