| # | Player | Position | Citizenship | Club | League goals | Assists | Apps | Seasons |
|---|---|---|---|---|---|---|---|---|
| 1 |  Francesco Totti | Attack - Second Striker | Italy | Retired | 250 | 158 | 618 | 25 |
| 2 |  Antonio Di Natale | Attack - Centre-Forward | Italy | Retired | 209 | 68 | 445 | 14 |
| 3 |  Ciro Immobile | Attack - Centre-Forward | Italy | Bologna FC 1909 | 201 | 51 | 354 | 14 |
| 4 |  Alessandro Del Piero | Attack - Second Striker | Italy | Retired | 188 | 109 | 478 | 18 |
| 5 |  Fabio Quagliarella | Attack - Centre-Forward | Italy | Retired | 182 | 53 | 556 | 20 |
| 6 |  Zlatan Ibrahimović | Attack - Centre-Forward | Sweden Bosnia-Herzegovina | Retired | 156 | 66 | 283 | 11 |
| 7 |  Filippo Inzaghi | Attack - Centre-Forward | Italy | Retired | 156 | 39 | 370 | 17 |
| 8 |  Hernán Crespo | Attack - Centre-Forward | Argentina Italy | Retired | 153 | 34 | 340 | 14 |
| 9 |  Marco Di Vaio | Attack - Centre-Forward | Italy | Retired | 142 | 35 | 342 | 13 |
| 10 |  Christian Vieri | Attack - Centre-Forward | Italy Australia | Retired | 142 | 27 | 264 | 16 |
| 11 |  Vincenzo Montella | Attack - Centre-Forward | Italy | Retired | 141 | 32 | 288 | 13 |
| 12 |  Paulo Dybala | Attack - Second Striker | Argentina Italy | AS Roma | 129 | 74 | 350 | 13 |
| 13 |  Andriy Shevchenko | Attack - Centre-Forward | Ukraine | Retired | 127 | 29 | 226 | 8 |
| 14 |  Gonzalo Higuaín | Attack - Centre-Forward | Argentina France | Retired | 125 | 35 | 224 | 7 |
| 15 |  Duván Zapata | Attack - Centre-Forward | Colombia | Torino FC | 124 | 50 | 326 | 13 |
| 16 |  David Trezeguet | Attack - Centre-Forward | France Argentina | Retired | 123 | 25 | 214 | 9 |
| 17 |  Domenico Berardi | Attack - Right Winger | Italy | US Sassuolo | 123 | 83 | 316 | 12 |
| 18 |  Mauro Icardi | Attack - Centre-Forward | Argentina Italy | Galatasaray | 121 | 31 | 219 | 7 |
| 19 |  Cristiano Lucarelli | Attack - Centre-Forward | Italy | Retired | 120 | 18 | 302 | 12 |
| 20 |  Lautaro Martínez | Attack - Centre-Forward | Argentina | Inter Milan | 116 | 39 | 239 | 8 |
| 21 |  Giampaolo Pazzini | Attack - Centre-Forward | Italy | Retired | 115 | 21 | 383 | 15 |
| 22 |  Andrea Belotti | Attack - Centre-Forward | Italy | Cagliari Calcio | 114 | 32 | 348 | 11 |
| 23 |  Nicola Amoruso | Attack - Centre-Forward | Italy | Retired | 113 | 25 | 380 | 16 |
| 24 |  Dries Mertens | Attack - Second Striker | Belgium | Retired | 113 | 66 | 295 | 9 |
| 25 |  Sergio Pellissier | Attack - Centre-Forward | Italy | Retired | 112 | 36 | 459 | 16 |